NBP Relieves Cardiac Injury and Reduce Oxidative Stress and Cell Apoptosis in Heart Failure Mice by Activating Nrf2/HO-1/Ca²⁺-SERCA2a Axis

Figure 5

The therapeutic effect of NPB treatment on myocardium in HF mice was partially reversed by CaMKII antagonist. (a) The results of HE staining showed the pathological changes in myocardial tissues (scale bar = 50 µm); (b) The results of Masson staining showed the tissue fibrosis (scale bar = 50 µm); (c) The results of TUNEL staining show the myocardial apoptosis rate (scale bar = 20 µm); (d) The natriuretic peptide levels were examined by ELISA; ‘’. n = 3.