Polysaccharides Extracted from Angelica sinensis (Oliv.) Diels Relieve the Malignant Characteristics of Glioma Cells through Regulating the MiR-373-3p-Mediated TGF-β/Smad4 Signaling Pathway

Figure 1

ASP inhibited the malignant characteristics of U251 cells. (a) Cell viability was measured by CCK-8 assay; (b) cell apoptosis was measured by flow cytometry; (c) cell migration was measured by wound healing assay; (d) cell invasion was measured by Transwell assay. U251 cells were treated with different concentrations of ASP (0, 0.1, 0.2, and 0.4 mg/mL) for 48 h; , , vs. control; ^#, ^### vs. 0.1 mg/mL ASP; ^&&, ^&&&vs. 0.2 mg/mL ASP. ASP upregulates miR-373-3p and blocks the TGF-β/Smad4 signaling pathway in glioma cells.

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