Mechanistic Research into the Effects of the Jianpi Xiaozhi Formula on Liver Injury in Diabetic Rats

Table 1

Comparison of general serological indexes of the rats in different groups after 8 weeks of JPXZF intervention.

Groups	NC group	DM group	DM + JL group	DM + JM group	DM + JH group	DM + PBA group
FBG (mmol/L)	4.83 ± 0.19	11.57 ± 0.68^a	11.33 ± 0.58^a	11.19 ± 0.50^a	5.43 ± 0.60^abc	5.38 ± 0.49^abc
FINS (uIU/mL)	18.89 ± 2.21	30.02 ± 6.82^a	24.75 ± 5.53^ab	22.72 ± 4.01^b	19.82 ± 2.48^bc	22.98 ± 4.09^b
TG (mmol/L)	0.90 ± 0.10	3.09 ± 0.24^a	2.90 ± 0.16^ab	1.99 ± 0.96^ab	1.50 ± 0.17^abc	1.97 ± 0.10^abc
TC (mmol/L)	3.57 ± 0.38	6.54 ± 0.34^a	6.44 ± 0.29^a	6.25 ± 0.24^a	5.71 ± 0.30^abc	6.03 ± 0.17^abc
ALT (U/L)	40.64 ± 4.24	44.32 ± 7.69	44.54 ± 7.77	42.67 ± 6.22	43.28 ± 6.77	42.03 ± 5.76
AST (U/L)	46.17 ± 3.25	48.29 ± 3.96	49.10 ± 5.00	46.70 ± 4.66	47.59 ± 3.79	48.82 ± 2.35
Body weight (g)	345.5 ± 10.39	428.13 ± 40.20^a	394.38 ± 35.73^ab	373.88 ± 31.90^b	352.88 ± 18.26^bc	374.25 ± 30.16^b

Normal control (NC) group: healthy untreated rats; diabetes mellitus (DM) group: rat models of DM; DM + JL group: diabetic rats treated with low-dosage Jianpi Xiaozhi Formula (JPXZF) (4.5 g/kg/d); DM + JM group: diabetic rats treated with an intermediate JPXZF dosage (9 g/kg/d); DM + JH group: diabetic rats treated with high-dosage JPXZF (18 g/kg/d); and DM + PBA group: diabetic rats treated with 4-phenylbutyric acid (PBA; 2.5 mg/kg/d). FBG, fasting blood glucose; FINS, fasting insulin; TG, triglyceride; TC, total cholesterol; ALT, alanine aminotransferase; AST, aspartic acid aminotransferase. The data are expressed as the means ± standard deviation. compared with the NC group; compared with the DM group; compared with the DM + JL group.