Antiplasmodial Activity of 80% Methanolic Extract and Solvent Fractions of Stem Bark of Acacia tortilis in Swiss Albino Mice

Table 2

Effects of crude extract and solvent fractions of Acacia tortilis on the parasitemia level and mean survival time in the 4-day suppressive test.

Treatment and doses	% Parasitemia	% Suppression	Mean survival time (days)
10 ml/kg DW	31.83 ± 1.17	0.00	6.00 ± 0.58
CHQ 25 mg/kg	0.00 ± 0.00^a3	100.00	30.00 ± 0.00^a3
100 mg/kg CE	19.67 ± 1.52^a3,b3	38.20	9.17 ± 0.60^a2,b3,e3
200 mg/kg CE	18.33 ± 1.23^a3,b3	42.41	11.17 ± 0.60^a3,b3,e3
400 mg/kg CE	15.50 ± 0.67^a3,b3	51.30	15.00 ± 0.58^a3,b3
100 mg/kg AF	29.67 ± 1.05^b3,e2	6.79	7.33 ± 0.42^b3,e3
200 mg/kg AF	28.50 ± 0.76^b3,e1	10.46	8.33 ± 0.80^a1,b3,e2
400 mg/kg AF	24.50 ± 1.06^a1,b3	23.03	11.33 ± 0.49^a2,b3
10 ml/kg 2% T 80	31.33 ± 1.05	0.00	6.67 ± 0.67
CHQ 25 mg/kg	0.00 ± 0.00^a3	100.00	30.00 ± 0.00^a3
100 mg/kg DF	22.67 ± 1.17^a3,b3,d1,e3	27.64	9.00 ± 0.82^a2,b3,d3,e3
200 mg/kg DF	17.50 ± 1.26^a3,b3	44.14	15.50 ± 1.12^a3,b3,c3
400 mg/kg DF	13.67 ± 0.99^a3,b3	56.37	17.33 ± 1.11^a3,b3,c3
100 mg/kg HF	30.17 ± 1.47^b3	3.70	7.67 ± 0.49^b3,e1
200 mg/kg HF	28.33 ± 0.88^b3	9.58	8.00 ± 0.58^b3
400 mg/kg HF	27.50 ± 0.99^b3	12.22	10.17 ± 0.87^a1,b3

Data are expressed as mean ± SEM; n = 6, a = compared to the negative control, b = compared to the positive control, c = compared to 100 mg/kg, d = compared to 200 mg/kg, e = compared to 400 mg/kg, ¹, ², ³,  = negative and positive controls for dichloromethane and hexane fractions, SEM = standard error of the mean, D0 = day 0, D4 = day 4, DW = distilled water, CE = crude extract, AF = aqueous fraction, DF = dichloromethane fraction, HF = hexane fraction, T80 = tween-80, and CHQ = chloroquine.