Research Article

Antiplasmodial Activity of 80% Methanolic Extract and Solvent Fractions of Stem Bark of Acacia tortilis in Swiss Albino Mice

Table 5

Packed cell volume (PCV), weight, and temperature for the crude extract and dichloromethane fraction of the stem bark of Acacia tortilis in the curative test.

GroupsPCVRectal temperature (°C)Body weight (g)
D3D7% ChangeD3D7% ChangeD3D7% Change

10 ml/kg DW50.00 ± 1.2940.33 ± 1.47−9.67 ± 1.5635.27 ± 0.2733.58 ± 0.23−1.68 ± 0.2519.00 ± 1.3716.00 ± 1.06−3.00 ± 0.37
CHQ 25 mg/kg50.50 ± 0.7649.67 ± 0.66a3−0.83 ± 1.66a335.92 ± 0.2336.60 ± 0.15a30.68 ± 0.26a324.17 ± 0.9824.00 ± 0.85a3−0.59 ± 0.59a2
100 mg/kg CE51.33 ± 0.6643.83 ± 1.51b2−7.50 ± 1.02b235.23 ± 0.2533.45 ± 0.12b3,d2−1.78 ± 0.28b324.67 ± 1.0222.00 ± 0.89a2−2.67 ± 0.42
200 mg/kg CE50.67 ± 0.4946.50 ± 0.76b1−4.17 ± 1.07a235.78 ± 0.1734.47 ± 0.35b3−1.32 ± 0.19a1,b324.00 ± 1.4323.33 ± 1.35a3−2.71 ± 0.88
400 mg/kg CE48.33 ± 0.8044.83 ± 0.79b1−3.50 ± 0.99a235.78 ± 0.0934.75 ± 0.15b3,c2−1.03 ± 0.11a1,b324.83 ± 0.8722.83 ± 0.70a3−2.00 ± 0.68a1
10 ml/kg 2% T 8047.17 ± 2.2439.17 ± 2.54−17.16 ± 2.7135.70 ± 0.2534.10 ± 0.26−4.48 ± 0.0321.67 ± 0.9519.83 ± 0.98−8.57 ± 0.90
CHQ 25 mg/kg46.83 ± 2.5747.83 ± 2.84a12.17 ± 0.69a336.23 ± 0.0937.23 ± 0.08a32.76 ± 0.00a326.83 ± 1.0426.67 ± 1.05a3−0.62 ± 0.61a3
100 mg/kg DF47.17 ± 1.3046.17 ± 1.40−2.13 ± 0.55a335.75 ± 0.0934.35 ± 0.09b3−3.92 ± 0.01a3,b3,d322.33 ± 1.0220.33 ± 1.02b3−9.05 ± 0.42b3,e1
200 mg/kg DF49.83 ± 1.1448.83 ± 1.30−2.01 ± 0.56a335.38 ± 0.0834.08 ± 0.07b3−3.67 ± 0.01a3,b3,e322.33 ± 0.9521.00 ± 1.06b2−6.11 ± 1.10b3
400 mg/kg DF52.17 ± 2.2450.17 ± 2.12−1.93 ± 0.45a3,b135.23 ± 0.1234.13 ± 0.12b3−3.12 ± 0.01a3,b3,c324.33 ± 0.8423.00 ± 0.68−5.39 ± 0.69a1,b2

Data are expressed as mean ± SEM; n = 6, a = compared to the negative control, b = compared to the positive control, c = compared to 100 mg/kg dose, d = compared to 200 mg/kg dose, e = compared to 400 mg/kg dose, 1, 2, 3,  = negative and positive controls for the dichloromethane fraction, D0 = day 0, D4 = day 4, DW = distilled water, CE = crude extract, DF = dichloromethane fraction, T 80 = tween 80, and CHQ = chloroquine.