Antiplasmodial Activity of 80% Methanolic Extract and Solvent Fractions of Stem Bark of Acacia tortilis in Swiss Albino Mice

Table 6

Effects of the crude extract and solvent fractions of Acacia tortilis on the parasitemia level and mean survival time in the prophylactic test.

Treatment and doses	% Parasitemia	% Suppression	Mean survival time (days)
10 ml/kg DW	29.00 ± 1.06	—	7.33 ± 1.50
CHQ 25 mg/kg	0.33 ± 0.33^a3	98.86	29.50 ± 1.22^a3
100 mg/kg CE	20.50 ± 1.40^a3,b3	29.31	11.33 ± 1.63^a2,b3,e3
200 mg/kg CE	17.83 ± 1.13^a3,b3	38.51	12.83 ± 0.98^a3,b3,e1
400 mg/kg CE	15.33 ± 0.55^a3,b3,c2	47.13	15.83 ± 1.72^a3,b3
10 ml/kg 2% T 80	31.00 ± 0.57	—	6.67 ± 0.49
CHQ 25 mg/kg	0.00 ± 0.00^a3	100	30.00 ± 0.00^a3
100 mg/kg DF	24.17 ± 1.07^a3,b3	22.03	9.50 ± 0.67^a2,b3
200 mg/kg DF	19.00 ± 1.34^a3,b3	38.70	16.33 ± 0.84^a3,b3
400 mg/kg DF	15.83 ± 0.87^a3,b3	48.93	17.50 ± 1.47^a3,b2

Data are expressed as mean ± SEM; n = 6, a = compared to the negative control, b = compared to the positive control, c = compared to 100 mg/kg dose, d = compared to 200 mg/kg dose, e = compared to 400 mg/kg dose, ¹, ², ³,  = negative and positive controls for the dichloromethane fraction, D0 = day 0, D4 = day 4, DW = distilled water, CE = crude extract, DF = dichloromethane fraction, T 80 = tween 80, and CHQ = chloroquine.