In Vivo Anti-Inflammatory, Analgesic, Sedative, Muscle Relaxant Activities and Molecular Docking Analysis of Phytochemicals from Euphorbia pulcherrima

Table 1

Analgesic effect of compounds (1 and 2) isolated from E. pulcherrima.

Group	Dose (mg/kg)	Time in minutes
		30	60	90	120
Normal saline	10 mL	9.25 ± 0.07	9.24 ± 0.08	9.25 ± 0.15	9.23 ± 0.11
Tramadol	10	25.00 ± 0.08	26.28 ± 0.07	25.50 ± 0.06	25.70 ± 0.11
Compound 1	5	11.55 ± 0.30	12.90 ± 0.43	12.80 ± 0.35	12.77 ± 0.40
	10	14.98 ± 0.98	15.55 ± 0.21	15.30 ± 0.45	15.20 ± 0.46
	15	17.32 ± 0.40	18.90 ± 0.33	18.30 ± 0.43	18.20 ± 0.49
	20	20.00 ± 0.33	21.03 ± 0.23	20.88 ± 0.32	20.80 ± 0.55
Compound 2	5	13.66 ± 0.10	14.96 ± 0.18	14.80 ± 0.20	14.60 ± 0.45
	10	16.90 ± 0.39	17.55 ± 0.23	17.36 ± 0.43	17.31 ± 0.55
	15	19.80 ± 0.21	20.93 ± 0.27	20.88 ± 0.40	20.59 ± 0.40
	20	22.98 ± 0.60	23.84 ± 0.73	23.70 ± 0.80	23.65 ± 0.90

The recorded results are represented as the mean ± SEM of all animals’ tolerance to thermal stimuli in seconds.