In Vivo Anti-Inflammatory, Analgesic, Sedative, Muscle Relaxant Activities and Molecular Docking Analysis of Phytochemicals from Euphorbia pulcherrima

Table 3

Muscle relaxant effect of compounds (1 and 2) isolated from E. pulcherrima.

Group	Dose (mg/kg)	Inclined plane test (% effect)			Traction test (effect)
		30 mints	60 mints	90 mints	30 mints	60 mints	90 mints
Distilled water	10 mL	0.00 ± 0	0.00 ± 0	0.00 ± 0	0.00 ± 0	0.00 ± 0	0.00 ± 0
Diazepam	1	100 ± 0.00	100 ± 0.00	100 ± 0.00	100 ± 0.00	100 ± 0.00	100 ± 0.00
Compound 1	5	25.32 ± 1.44	29.90 ± 1.37	31.66 ± 1.20	26.61 ± 1.32	27.22 ± 1.00	26.09 ± 1.33
	10	30.22 ± 1.40	34.65 ± 1.33	36.98 ± 1.34	31.88 ± 1.34	32.67 ± 1.03	31.07 ± 1.20
	15	40.23 ± 1.35	47.09 ± 1.32	48.67 ± 1.18	41.34 ± 1.09	42.34 ± 1.04	41.22 ± 1.18
	20	46.09 ± 1.36	52.00 ± 1.28	53.99 ± 1.23	47.32 ± 1.05	48.23 ± 1.06	47.23 ± 1.23
Compound 2	5	30.21 ± 1.23	36.87 ± 1.45	37.32 ± 1.02	31.11 ± 1.09	32.034 ± 1.00	31.98 ± 1.32
	10	36.09 ± 1.67	43.34 ± 1.32	45.23 ± 1.07	37.23 ± 1.23	38.012 ± 1.34	37.56 ± 1.07
	15	47.03 ± 1.40	55.13 ± 1.22	57.45 ± 1.44	48.87 ± 1.09	49.03 ± 1.09	47.66 ± 1.23
	20	55.08 ± 1.33	63.11 ± 1.00	64.98 ± 1.76	56.32 ± 1.23	58.02 ± 1.23	56.76 ± 1.02

The recorded results are represented as the mean ± SEM of all animals’ tolerance to thermal stimuli in seconds.