In Vivo Anti-Inflammatory, Analgesic, Sedative, Muscle Relaxant Activities and Molecular Docking Analysis of Phytochemicals from Euphorbia pulcherrima

Table 4

Binding energy and inhibition constant of the spinacetin (1) and patuletin (2) calculated by AutoDock into the binding site of μ-opioid and GABA_A receptors.

Compound no.	GABAA receptor (PDB Id: 4COF)			μ-opioid receptor (PDB Id: 5C1M)
	MOE	AutoDock		MOE	AutoDock
	BE (kcal/mol)	BE (kcal/mol)	Ki (μM)	BE (kcal/mol)	BE (kcal/mol)	Ki (μM)
1	−5.8221	−6.49	17.44	−7.1978	−7.89	4.84
2	−5.8935	−6.33	22.82	−6.7992	−7.11	6.19