[Retracted] Inhibition of miR-29b-1-5p Attenuates Inflammatory Response and Pulmonary Fibrosis in LPS-Induced Acute Lung Injury by Regulating RTN4 Expression

Figure 5

miR-29b-1-5p mediated pulmonary interstitial fibrosis in the ALI animal model by targeting RTN4. LPS-induced ALI mice were injected with miR-29b-1-5p agomir, miR-29b-1-5p antagomir, miR-29b-1-5p NC, RTN4 expression vector, and empty vector alone or in combination as required via caudal vein to manipulate the expression of miR-29b-1-5p and RTN4 in vivo. (a) The mRNA levels of TGF-β1, E-cadherin, α-SMA, and vimentin in LPS-induced ALI mouse lung tissues were determined using qRT-PCR. (b) The protein expressions of TGF-β1, E-cadherin, α-SMA, and vimentin in LPS-induced ALI mouse lung tissues were determined using Western blot analysis. , vs. LPS-induced ALI mice and ^# vs. miR-29b-1-5p agomir.

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