Network Pharmacology Analysis and Experimental Verification Strategies Reveal the Action Mechanism of Danshen Decoction in Treating Ischemic Cardiomyopathy

Table 2

Molecular docking verification.

Target gene	PDB ID	Compound	Formula	Molecular docking diagram	Binding site	Docking diagrams (kcal/mol)
TP53	2J21	Luteolin	C15H10O6		ASP A:268, ASN A:131, TYR A:126, GLN A:104, PHE A:113, HIS A:115, ARG A:110	−7.0
		Tanshinone IIA	C19H18O3		GLN A:192, ARG A:174, HIS A:214, ASP A:207, VAL A:172, PHE A:212	−7.1
AKT1	4GV1	Luteolin	C15H10O6		GLU-234, ALA-230, LYS-158, THR A:291, MET A:281, ALA A:177, VAL A:164	−8.1
JUN	1Jun	Luteolin	C15H10O6		GLU A:303, ASN A:299, ARG A:302, ALA A:306	−5.1
		Tanshinone IIA	C19H18O3		LYS A:309, GLN A:310, ALA A:306, VAL A:305, ARG:320, LEU A:301	−6.0
		β-sitosterol	C29H50O		LYS A:309, VAL A:305, LEU A:301, ALA A:306, ARG A:302, ALA A:298	−5.8