Astragaloside IV Improves the Barrier Damage in Diabetic Glomerular Endothelial Cells Stimulated by High Glucose and High Insulin

Table 1

Effects of astragaloside IV on inflammation and oxidative stress factors.

Group	TNFα (intracellular), ng/L	TNFα (extracellular), ng/L	IL-1β (intracellular), ng/L	IL-1β (extracellular), ng/L	SOD, U/mg prot	MDA, nmol/mg prot
Control	398.61 ± 3.95	352.24 ± 1.91	659.89 ± 2.79	644.23 ± 7.11	271.55 ± 4.66	3.93 ± 0.21
H-Glu + Ins	461.39 ± 9.1	505.92 ± 9.53	814.75 ± 8.54	754.77 ± 3.48	143.53 ± 26.16	8.48 ± 0.25
H-Glu + Ins + AS-IV	412.8 ± 5.38^###	376.09 ± 3.31^###	735.3 ± 2.84^###	687.3 ± 6.84^###	254.66 ± 5.31^###	5.41 ± 0.18^###

 < 0.01 vs. control; ^### < 0.01 vs. H-Glu + Ins.