Downregulation of Circ-PITHD1 Suppressed Colorectal Cancer via Glycolysis Inhibition through miR-590-5p/HK2 Axis

Figure 5

Overexpression of HK2 or inhibition of miR-590-5p reversed CRC cells proliferation and invasion after silencing circ-PITHD1. (a, b) CCK8 detection shows the proliferation ability of Lovo and SW480 cells. The data are expressed as the mean ± SD. vs. NC. ^### vs. si-circ-PITHD1. (c–e) Cloning formation assay shows the cell proliferation in both Lovo and SW480 cells. The data are expressed as the mean ± SD. , vs. NC. ^### vs. si-circ-PITHD1. (f–h) Transwell detection shows the invasion and migration of Lovo and SW480 cells. The data are expressed as the mean ± SD. , vs. NC. ^### vs. si-circ-PITHD1.

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