Vasorelaxant Effects of the Vitex Agnus-Castus Extract

Figure 1

Concentration-dependent relaxant effect of VACE on PE-, KCl, -induced ASM contractions. (a). Original representative tracings in force/time of isolated rabbit ASM before (untreated) and after PE (0.5 μM)-induced contraction followed by the addition of cumulative concentrations (0.15–0.75 mg/mL) of VACE. Arithmetic means ± SEM (n = 4-5 aortic rings, each from a different animal) of the relaxant effects of VACE cumulative concentrations (0.15–0.75 mg/mL, gray bars) on rabbit ASM induced by PE (0.5 μM, black bar) (b) and KCl (80 mM, black bar), respectively (c). All results are shown as a value of the 1 g of contraction response. Statistically significant difference from the respective VACE concentration in rabbit aorta compared to PE and KCl alone, respectively. , , and .

(a)

(b)

(c)