Verbena Attenuates Adriamycin-Induced Renal Tubular Injury via Inhibition of ROS-ERK1/2-NLRP3 Signal Pathway

Figure 5

TAEV attenuates ADR-induced renal tubular injury via inhibition of ROS-mediated ERK1/2 and NLRP3 activation. (a and b) Cells were incubated with ADR (1 μg/mL) for corresponding times (, , and ). (c and d) Cells pretreated with TAEV (1 mg/mL) and NAC (10 μM) for 1 h were incubated with ADR for another 9 h. (^##, ^#### versus control, and versus ADR). (e and f) Cells were pretreated with TAEV (1 mg/mL), NAC (10 μM), U0126 (20 μM), and INF39 (100 μM) for 1 h and incubated with ADR (1 μg/mL) for another 24 h. Cell viability was tested using CCK-8. (^## versus control and , , and versus ADR).

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