Transcriptomic Profile Analysis of Streptococcus mutans Response to Acmella paniculata Flower Extracts

Table 6

Log₂ fold change of downregulated genes in APFD-treated S. mutans.

Gene name	Log2 fold change	value	Gene description
SmuNN2025_1359	−1.6044657	2.09E−29	DNA polymerase III, delta subunit
ssb	−0.6788083	1.88E−14	Putative single-stranded DNA-binding protein
dnaG	−0.5734505	3.44E−11	DNA primase catalytic core, N-terminal domain
rnh3	−0.3960807	0.00051026	Putative ribonuclease PF01351: ribonuclease HII
holB	−0.3897243	0.00139286	Putative DNA polymerase III delta subunit
murD	−0.855528	1.69E−14	Putative D-glutamic acid adding enzyme
uppS	−1.1305843	1.94E−14	Putative undecaprenyl pyrophosphate synthetase
murC2	−0.7820073	1.92E−11	Putative UDP-N-acetylmuramyl tripeptide synthetase
pbp2b	−0.5783955	4.89E−09	Penicillin-binding protein dimerisation domain
murE	−0.4486175	3.23E−05	Putative UDP-N-acetylmuramoyl-L-alanine-D-glutamate-
murN	−0.403607	0.00089	Putative peptidoglycan branched peptide synthesis protein
murB	−0.440412	0.002353	Putative UDP-N-acetylenolpyruvoylglucosamine reductase

The genes were involved in biosynthesis peptidoglycan and DNA replication pathway (KEGG).