Role of Estrogen Receptor-Positive/Negative Ratios in Regulating Breast Cancer

<div>Invasion and migration assay <i>in vitro</i>. (a) 1/2: The numbers of cells that crossed the Matrigel filter showed that cell invasion ability significantly stabilized at 40% and 70% ER<i>α</i>+/ER<i>α</i>−ratio. (b) 1/2: Compared to the MCF-7 group (control), in the 70% ER<i>α</i>+/ER<i>α</i>− ratio group, the most cells migrated rapidly and scratches became significantly narrow after 24h; after 48 h, the scratches were completely filled with cells.</div>

Evidence-Based Complementary and Alternative Medicine

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Figure 3

Figure 3: Role of Estrogen Receptor-Positive/Negative Ratios in Regulating Breast Cancer 