A Chinese Medicine Compound Alleviates Cisplatin-Induced Acute Kidney Injury via Its Antiapoptosis and Anti-Inflammation Effects in Mice

<div>JPYST ameliorates CDDP-induced renal apoptosis levels. (a) Apoptosis of renal tissue sections was analyzed by the TUNEL assay. Arrows show TUNEL-positive cells in renal tubular area (400x). Scale bar, 100 <i>μ</i>m. (b) Quantification of TUNEL-positive cells in cortical renal tubular. (c) Western blots showing patterns of cleaved-caspase-3, Bad, and Bax protein expressions in renal tissues. (d)–(f) Quantitative analysis of cleaved-caspase-3, Bad, and Bax protein expression in the renal tissues. (g) Representative immunohistochemistry (IHC) images of Bcl-2 protein in renal cortical glomeruli and tubular epithelium (400x). Scale bar, 100 <i>μ</i>m (h) Quantitative analysis of IHC for the Bcl-2 protein expression. AOD = IOD/area. 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Evidence-Based Complementary and Alternative Medicine

fig2

Figure 2

Figure 2: A Chinese Medicine Compound Alleviates Cisplatin-Induced Acute Kidney Injury via Its Antiapoptosis and Anti-Inflammation Effects in Mice 