Toxicological Evaluation of Camellia euphlebia Leaves Aqueous Extract Using Acute and Subacute Toxicity Studies in Mice and Genotoxicity Studies

Table 1

Effects of intragastric administration of CEAE three times a day on mice.

Parameters	Groups
	Control	CEAE (1000 mg/kg)	CEAE (2000 mg/kg)	CEAE (4000 mg/kg)	CEAE (5000 mg/kg)
Mortality (%)	0	0	0	0	0
Toxic symptoms	None	None	None	Sedation and hyperventilation	Sedation and hyperventilation
Body weight (g)	30.33 ± 2.65^a	29.90 ± 1.51^a	30.35 ± 1.55^a	30.08 ± 2.55^a	31.08 ± 1.61^a
Liver weight (%)	2.32 ± 0.08^a	1.98 ± 0.23^a	2.15 ± 0.48^a	2.29 ± 0.23^a	2.27 ± 0.23^a
Kidney weight (%)	0.53 ± 0.04^a	0.47 ± 0.06^a	0.50 ± 0.09^a	0.44 ± 0.03^a	0.50 ± 0.08^a
Spleen weight (%)	0.13 ± 0.01^a	0.14 ± 0.01^a	0.15 ± 0.02^a	0.14 ± 0.04^a	0.14 ± 0.03^a

Within each row, values with the same superscripts are not significantly different from each other ( < 0.05), as determined by Tukey’s t-test. CEAE: C. euphlebia aqueous extract.