Toxicological Evaluation of Camellia euphlebia Leaves Aqueous Extract Using Acute and Subacute Toxicity Studies in Mice and Genotoxicity Studies

Table 2

Effects of intragastric administration of CEAE for consecutive 14 days on the physiological indices in mice.

Parameters	Groups
	Control	CEAE (400 mg/kg)	CEAE (800 mg/kg)	CEAE (1600 mg/kg)
Mortality (%)	0	0	0	0
Toxic symptoms	None	None	None	Sedation, piloerection, and hyperventilation
Food intake (g)	7.6	9.2	8.4	7.6
Water intake (mL)	12	8.0	7.0	12
Weight gain (g)	4.16 ± 0.64^a	4.18 ± 0.73^a	3.43 ± 0.99^a	3.32 ± 1.12^a
Liver weight (%)	4.32 ± 0.44^a	4.40 ± 0.87^a	4.30 ± 0.36^a	4.48 ± 0.35^a
Spleen weight (%)	0.31 ± 0.04^a	0.32 ± 0.04^a	0.31 ± 0.04^a	0.34 ± 0.04^a
Kidney weight (%)	1.20 ± 0.12^a	1.27 ± 0.10^a	1.20 ± 0.10^a	1.23 ± 0.11^a
White blood cells (×10^9/L)	5.95 ± 0.78^a	5.41 ± 0.59^a	5.83 ± 1.01^a	5.69 ± 1.15^a
Red blood cells (×10^12/L)	6.46 ± 1.24^a	5.57 ± 1.27^a	5.39 ± 0.98^a	5.36 ± 1.07^a
Creatinine (µmol/L)	62.62 ± 7.48^a	59.56 ± 8.55^a	61.50 ± 6.90^a	59.66 ± 10.70^a
AST (U/gprot)	65.99 ± 7.18^a	59.12 ± 7.26^a	65.53 ± 8.13^a	66.15 ± 8.61^a
ALT (U/gprot)	23.93 ± 4.84^a	26.92 ± 4.95^a	30.19 ± 5.52^a	30.79 ± 8.14^a

Within each row, values with the same superscripts are not significantly different from each other ( < 0.05), as determined by Tukey’s t-test. CEAE: C. euphlebia aqueous extract.