Toxicological Evaluation of Camellia euphlebia Leaves Aqueous Extract Using Acute and Subacute Toxicity Studies in Mice and Genotoxicity Studies

Table 3

Effects of intragastric administration of CEAE for consecutive 28 days on the physiological indices in mice.

Parameters	Groups
	Control	CEAE (200 mg/kg)	CEAE (400 mg/kg)	CEAE (600 mg/kg)
Mortality (%)	0	0	0	0
Toxic symptoms	None	None	None	None
Food intake (g)	10.30	8.95	9.70	9.80
Water intake (mL)	14	13	12	13
Body weight (g)	39.74 ± 2.05^a	39.07 ± 2.48^a	39.89 ± 3.52^a	40.95 ± 2.20^a
Liver weight (%)	4.96 ± 0.05^a	4.95 ± 0.43^a	4.89 ± 0.26^a	4.78 ± 0.42^a
Spleen weight (%)	0.30 ± 0.06^a	0.38 ± 0.08^a	0.22 ± 0.07^a	0.35 ± 0.14^a
Kidney weight (%)	1.33 ± 0.12^a	1.41 ± 0.03^a	1.50 ± 0.15^a	1.57 ± 0.21^a
White blood cells (×10^9/L)	3.44 ± 0.46^a	3.70 ± 0.35^a	3.59 ± 0.50^a	3.85 ± 0.46^a
Red blood cells (×10^12/L)	3.48 ± 0.57^a	4.02 ± 0.78 ^ab	4.79 ± 0.72 ^ab	4.69 ± 0.43^b
Creatinine (µmol/L)	52.34 ± 7.31^a	59.09 ± 8.53^a	55.03 ± 9.72^a	65.37 ± 10.70^a
AST (U/L)	129.34 ± 12.73^a	131.26 ± 22.57^a	140.97 ± 21.31^a	145.26 ± 17.91^a
ALT (U/L)	49.88 ± 11.27^a	54.94 ± 15.31^a	56.42 ± 14.35^a	64.34 ± 10.88^a

Within each row, values with different superscripts are significantly different from each other ( < 0.05), as determined by Tukey's t-test. CEAE: C. euphlebia aqueous extract.