Toxicological Evaluation of Camellia euphlebia Leaves Aqueous Extract Using Acute and Subacute Toxicity Studies in Mice and Genotoxicity Studies

Table 4

In vitro chromosomal aberration test of CEAE in CHL fibroblast cells in the absence or presence of S9 metabolic activation.

Drugs	Doses (ug/mL)	Treatment time (h)	Recovery time (h)	S9 mixture	Structural aberrations (%)	Numerical aberrations (%)
Vehicle control	−	6	18	−	0	0
Mitomycin C	0.05	6	18	−	14.5	0.5
Cyclophosphamide	10	6	18	+	19.5	1.5
CEAE	750	6	18	−	0.5	0
CEAE	1500	6	18	−	2.5	1.5
CEAE	3000	6	18	−	1.5	0
Vehicle control	−	24	0	+	0.5	0.5
Mitomycin C	0.05	24	0	−	31	1
Cyclophosphamide	10	24	0	+	43.5	2.5
CEAE	300	24	0	+	0.5	0
CEAE	600	24	0	+	1	0
CEAE	1200	24	0	+	1	0.5

CEAE: C. euphlebia aqueous extract.