Evidence-Based Complementary and Alternative Medicine

Research Article

Network Pharmacology Combined with Molecular Docking and Experimental Verification Reveals the Bioactive Components and Potential Targets of Danlong Dingchuan Decoction against Asthma

Table 3

Effect of Danlong Dingchuan Decoction on the concentrations of TNF-α, IL-4, TGF-β1, IL-6, IL-8, and IL-1β in the lung tissue of asthmatic mice (± s, ng • mL⁻¹, n = 10).


Group	TNF-α (ng • mL⁻¹)	IL-4 (ng • mL⁻¹)	TGF-β1 (ng • mL⁻¹)	IL-6 (ng • mL⁻¹)	IL-8 (ng • mL⁻¹)	IL-1β (ng • mL⁻¹)

C	32.08 ± 6.36	36.05 ± 7.67	6077.89 ± 2287.15	44.97 ± 12.17	198.57 ± 46.36	50.31 ± 5.27
M	40.00 ± 4.05^∆∆	63.26 ± 14.99^∆∆	11397.99 ± 1785.00^∆∆	81.13 ± 18.99^△	438.25 ± 164.31^∆	136.06 ± 43.97^∆
W	32.74 ± 5.55	37.88 ± 10.89	7109.92 ± 1398.58	63.56 ± 18.37^∗	241.52 ± 41.25	56.12 ± 12.16
H	33.00 ± 3.23	60.37 ± 14.05	1700.25 ± 1569.72	47.69 ± 9.85	471.01 ± 163.81	48.01 ± 10.24
Z	32.52 ± 6.23	55.63 ± 9.11	11006.92 ± 1569.29	44.12 ± 9.00	253.13 ± 98.56	85.82 ± 54.60
L	31.96 ± 3.11	42.44 ± 12.847	7536.31 ± 1551.97	66.30 ± 17.15	319.23 ± 71.05	543.48 ± 193.11

Group C: blank control group; Group M: model group; Group W: prednisone group; Group H: Danlong Dingchuan Decoction high-dose group; Group Z: Danlong Dingchuan Decoction medium-dose group; Group L: Danlong Dingchuan Decoction low-dose group. Compared with the blank control group, ^ΔΔP < 0.01 and ; compared with the model group, and .