Research Article

The Effects and Mechanisms of Sennoside A on Inducing Cytotoxicity, Apoptosis, and Inhibiting Metastasis in Human Chondrosarcoma Cells

Figure 7

SA negatively regulated apoptosis, metastasis, and the Wnt/β-catenin pathways in chondrosarcoma cells. The levels of proteins relevant to apoptosis, metastasis, and the Wnt/β-catenin pathways were, respectively, quantified by western blotting. (a, b) The apoptosis-related proteins (Bcl-2, Bax) in SW1353 cells. (c, d) The metastasis-related proteins (E-cadherin, N-cadherin) in SW1353 cells. (e, f) Proteins in the Wnt/β-catenin pathway (WNT3A, β-Catenin, and c-Myc) in SW1353 cells. Relative protein expression was assayed by normalizing with GAPDH. Data are expressed as mean ± SEM (n = 3). , , vs. control.
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