Enhancing Cytotoxicity of Tamoxifen Using Geranium Oil

Figure 7

Geraniol attenuates ER-agonist activities. Geraniol attenuates (a) ERα- and (b) ERβ-agonist activities. Interactions between ERα/β and geraniol or citronellol at final concentrations equivalent to 25 μg/mL of Geranium oil (Table 1) or Geranium oil (final concentration: 25 μg/mL) were monitored using the RCAS for ERα and ERβ in the absence or presence of E2 (final concentration: 1 nM). The black graph represents ER agonist activity of positive control (1 nM E2). Data represent the mean ± standard error of the mean (n = 3). vs. the blank group; ^# vs. the E2 group.

(a)

(b)