Morroniside Protects Human Granulosa Cells against H₂O₂-Induced Oxidative Damage by Regulating the Nrf2 and MAPK Signaling Pathways

Figure 1

The effect of morroniside on GCs viability decreased by H₂O₂. (a) Structure of morroniside. (b) Ovarian GCs were treated with morroniside at different concentrations (including 1, 5, 10, 20, 50 μM) for 24 h. (c) GCs were treated with H₂O₂ at different concentrations (including 200, 400, 600, 800, 1000, 1500 μM) for 24 h. (d) GCs were pretreated with morroniside at different concentrations (including 5, 10, and 20 μM) for 24 h and then treated with 600 μM H₂O₂ for 24 h. The survival rates of GCs were determined by CCK-8 assay kit. Data represent mean ± SD, n = 6. ^# versus the control group, ^## versus the control group, versus the H₂O₂ group.

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