Morroniside Protects Human Granulosa Cells against H<sub>2</sub>O<sub>2</sub>-Induced Oxidative Damage by Regulating the Nrf2 and MAPK Signaling Pathways

<div>Schematic model of morroniside protecting human granulosa cells against H<sub>2</sub>O<sub>2</sub>-induced oxidative damage. Morroniside increased the expression level of p-Nrf2, promoted the nuclear translocation of Nrf2, and then upregulated the expression of antioxidant enzymes such as SOD and NQO1 which reduced the oxidative damage induced by H<sub>2</sub>O<sub>2</sub>. In addition, morroniside ameliorated p38 and JNK pathway-induced apoptosis by reducing ROS levels.</div>

Evidence-Based Complementary and Alternative Medicine

fig8

Figure 8

Figure 8: Morroniside Protects Human Granulosa Cells against H<sub>2</sub>O<sub>2</sub>-Induced Oxidative Damage by Regulating the Nrf2 and MAPK Signaling Pathways 

Evidence-Based Complementary and Alternative Medicine

Morroniside Protects Human Granulosa Cells against H2O2-Induced Oxidative Damage by Regulating the Nrf2 and MAPK Signaling Pathways

Figure 8

Morroniside Protects Human Granulosa Cells against H₂O₂-Induced Oxidative Damage by Regulating the Nrf2 and MAPK Signaling Pathways