Huangjia Ruangan Granule Inhibits Inflammation in a Rat Model with Liver Fibrosis by Regulating TNF/MAPK and NF-<i>κ</i>B Signaling Pathways

<div>HJRG prevents the injury of CCl<sub>4</sub> in rats. (a) Comparison of the body weight of rats in each group. (b) The Liver Index of rats in different groups (<i>n</i> = 12). (c) Appearance of the isolated liver of each group of rats. (d) HE staining of the liver tissue representative images (Magnification, 100X and 200X). (e) Concentrations of AST and ALT in the serum (<i>n</i> = 12). <svg height="11.7782pt" id="M3" style="vertical-align:-3.42938pt" version="1.1" viewbox="-0.0498162 -8.34882 50.7895 11.7782" width="50.7895pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M448 453H361L394 608H355L322 453H214L248 608H210L176 453H79L70 395H163L134 259H35L24 201H120L82 27H120L158 201H266L229 27H267L305 201H395L404 259H318L348 395H439L448 453ZM310 395L280 259H173L202 395H310Z"></path></g><g transform="matrix(.013,0,0,-0.013,6.24,0)"><path d="M570 304C570 398 525 448 414 448C385 448 343 445 312 434L329 511L321 518C297 504 262 482 244 460L233 411C195 397 159 381 128 358L135 332C160 347 189 360 224 373L111 -147C97 -210 84 -218 17 -231L13 -257L254 -247L259 -218L233 -216C183 -212 177 -202 189 -142L218 -1C238 -10 266 -12 283 -12C351 3 429 48 483 105C543 168 570 242 570 304ZM482 289C482 161 380 33 304 33C278 33 248 51 233 69L303 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453ZM310 395L280 259H173L202 395H310Z"></path></g><g transform="matrix(.013,0,0,-0.013,12.48,0)"><path d="M570 304C570 398 525 448 414 448C385 448 343 445 312 434L329 511L321 518C297 504 262 482 244 460L233 411C195 397 159 381 128 358L135 332C160 347 189 360 224 373L111 -147C97 -210 84 -218 17 -231L13 -257L254 -247L259 -218L233 -216C183 -212 177 -202 189 -142L218 -1C238 -10 266 -12 283 -12C351 3 429 48 483 105C543 168 570 242 570 304ZM482 289C482 161 380 33 304 33C278 33 248 51 233 69L303 396C326 400 352 403 369 403C428 403 482 380 482 289Z"></path></g><g transform="matrix(.013,0,0,-0.013,23.822,0)"><path d="M512 -3V55L134 254V256L512 456V514L75 281V230L512 -3Z"></path></g><g transform="matrix(.013,0,0,-0.013,35.085,0)"><path d="M241 635C89 635 35 457 35 312C35 153 89 -12 240 -12C390 -12 443 166 443 312C443 466 390 635 241 635ZM238 602C329 602 354 454 354 312C354 172 330 22 240 22C152 22 124 173 124 313S148 602 238 602Z"></path></g><g transform="matrix(.013,0,0,-0.013,41.325,0)"><path 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Control: control group; Model: model group; Silymarin: silymarin group; HJRG-L: Huangjia Ruangan granule low-dose group; HJRG-M: Huangjia Ruangan granule medium-dose group; HJRG-H: Huangjia Ruangan granule high-dose group.</div>

Evidence-Based Complementary and Alternative Medicine

fig2

Figure 2

Figure 2: Huangjia Ruangan Granule Inhibits Inflammation in a Rat Model with Liver Fibrosis by Regulating TNF/MAPK and NF-<i>κ</i>B Signaling Pathways 

Evidence-Based Complementary and Alternative Medicine

Huangjia Ruangan Granule Inhibits Inflammation in a Rat Model with Liver Fibrosis by Regulating TNF/MAPK and NF-κB Signaling Pathways

Figure 2