Evaluation of a Dual PI3K/mTOR Inhibitor PF-04691502 against Bladder Cancer Cells

Figure 1

PF-04691502 inhibits the viability, migration, and invasion of bladder cancer cells. (a) The chemical structure of PF-04691502. (b) T-24 and 5637 cells were treated with various doses of PF-04691502 for the specific times, and then, cellular viabilities were measured. (c) T-24 and 5637 cells were treated with various doses of PF-04691502 for 24 h and cellular migration distance was measured. (d) T-24 and 5637 cells were treated with various doses of PF-04691502 for 24 h and cellular invasion was measured. (e) T-24 and 5637 cells were treated with various doses of PF-04691502 for 24 h and the levels of the specific proteins were measured using western blotting. Data are representative of at least three independent experiments (; ).

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