The Effect of Curcumin on Lipid Profile and Glycemic Status of Patients with Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis

Table 1

Characteristics of the subjects included in the studies.

Author, year	Study design	Duration	Study group	N	Mean age (years)	Baseline values (mg/dl)
						Triglycerides	TC	LDL-c	HDL-c	FBG	HbA1c (%)
Adibian et al., 2019 [20]	RDP	10 weeks	Curcumin 1500 mg/d	21	58 ± 8	124 ± 36	167 ± 34	112 ± 31	30 ± 2	160 ± 35	11.3 ± 1.6
			Placebo	23	60 ± 7	126 ± 52	180 ± 47	125 ± 44	30 ± 2	144 ± 40.6	11.2 ± 1.3
Adab et al., 2019 [21]	RDP	8 weeks	Turmeric 2100 mg/d	39	54.76 ± 6.00	181.56 ± 79.79	148.85 ± 36.11	82.56 ± 20.99	38.79 ± 10.30	133.79 ± 25.60	7.06 ± 1.01
			Placebo	36	55.66 ± 8.64	164.05 ± 81.19	155.36 ± 36.27	86.61 ± 21.99	44.63 ± 10.66	129.91 ± 32.98	6.79 ± 1.08
Abbood, 2018 [22]	RP	12 weeks	Curcumin 1000 mg/d	16	46.76 ± 7.89	193.15 ± 59.36	214.18 ± 60.31	109.02 ± 12.76	46.01 ± 9.28	190.44 ± 51.48	8.0 ± 0.91
			Atorvastatin 20 mg/d	16		225.93 ± 135.56	262.5 ± 68.43	114.43 ± 53.74	53.74 ± 9.67	214.56 ± 57.96	8.19 ± 1.24
			Placebo	16		170.11 ± 73.54	223.07 ± 48.33	105.16 ± 39.43	38.27 ± 11.6	210.24 ± 65.52	8.35 ± 1.93
Panahi et al., 2017 [12]	RDP	12weeks	Curcuminoids 1000 mg/d	50	43 ± 8	229.78 ± 81.84	217.34 ± 41.60	169.16 ± 30.77	40.86 ± 5.41	163 ± 37	7.4 ± 0.7
			Placebo	50	41 ± 7	207.62 ± 54.63	231.04 ± 70.95	199.06 ± 54.49	39.46 ± 6.09	174 ± 32	7.5 ± 0.9
Rahimi et al., 2016 [11]	RDP	3 months	Nano-curcumin 80 mg/d	35	56.34 ± 11.17	109 (94.75) #	163.4 ± 33.94	96.57 ± 33.94	54.30 ± 14.02	135.5 ± 51.33	7.59 ± 1.74
			Placebo	35	60.95 ± 10.77	142 (97.50) #	162.4 ± 38.59	99.78 ± 30.33	60.35 ± 15.96	148.30 ± 76.41	7.49 ± 1.75
Maithili et al., 2015 [23]	RP	4 weeks	Turmeric 2 g/d + Met 1 g/d	30	47 ± 7.17	120.56 ± 37.1	184.6 ± 14.6	124.4 ± 17	36.02 ± 8.1	116 ± 23	7.9 ± 1.3
			Met 1 g/d	30	46.8 ± 6.1	127.3 ± 33.3	181.5 ± 22.3	121.7 ± 26.3	34.3 ± 7.1	111 ± 24	7.8 ± 0.5
Na et al., 2013 [15]	RDP	3 months	Curcuminoids 300 mg/d	50	55.42 ± 6.40	2.23 ± 0.53	6.11 ± 1.13	4.30 ± 1.20	1.37 ± 0.26	8.58 ± 2.66	7.77 ± 1.82
			Placebo	50	54.72 ± 8.34	2.19 ± 1.04	6.08 ± 1.24	4.32 ± 1.15	1.33 ± 0.28	8.41 ± 2.17	7.72 ± 2.12
Khajehdehi et al., 2011 [24]	RDP	2 months	Turmeric 1500 mg/d	20	52.9 ± 9.2	236.2 ± 146.5	214.2 ± 66.5	114.1 ± 34.6	43.8 ± 12.6	179.0 ± 65.5
			Placebo	20	52.6 ± 9.7	220.4 ± 106.9	193.3 ± 45.7	108.3 ± 39.9	39.8 ± 9.5	169.54 ± 76.3
Usharani et al., 2008 [14]	RDP	8 weeks	Curcuminoids 600 mg/d	23	55.52 ± 10.76	176.39 ± 27.61	195.0 ± 41.16	120.35 ± 42.13	38.78 ± 7.69	155.04 ± 17.94	8.04 ± 0.85
			Atorvastatin 10 mg/d	23	50.47 ± 10.35	182.26 ± 43.85	196.78 ± 35.28	123.50 ± 38.73	36.82 ± 5.45	161.21 ± 19.74	8.30 ± 0.86
			Placebo	21	49.75 ± 8.18	170.14 ± 47.54	196.95 ± 35.72	125.29 ± 34.94	36.38 ± 7.67	161.19 ± 19.97	7.82 ± 0.57

Values are expressed as mean ± SD. ^#Values expressed as Median (IQR).