Research Article

Comparison of Pharmacokinetic Profiles of 14 Major Bioactive Components in Normal and Arthritic Model Rats after Oral Administration of Angelicae pubescentis Radix by UPLC-MS/MS

Table 1

The linear regression curve, correlation coefficient, and linear range of 14 compounds in rat plasma.

AnalytesRegression equationRLinear range (ng/mL)LLOQ (ng/mL)

Neochlorogenic acidy = 1.980x + 0.0130.9960.6–5040.6
Chlorogenic acidy = 1.842x + 0.0540.99210–318010
Cryptochlorogenic acidy = 1.747x − 0.0020.9932.5–2342.5
3,4-diCQAy = 1.578x + 0.0120.99610.7–11210.7
3,5-diCQAy = 1.010x + 0.0080.9972.5–6252.5
4,5-diCQAy = 1.487x + 0.0080.99510.0–20410.0
Columbianetiny = 29.151x + 0.0210.9983.9–45203.9
Psoraleny = 15.281x + 0.0050.9983.7–5053.7
Xanthotoxiny = 67.454x + 0.0470.9982.2–11202.2
Bergapteny = 71.002x + 0.0200.9974.8–6804.8
Columbianetin acetatey = 2.499x − 0.0080.9987.4–43207.4
Isoimperatoriny = 6.338x − 0.0170.9978.4–8908.4
Ostholy = 77.336x + 0.2710.9911.0–55001.0
Columbianadiny = 0.536x + 0.0140.9966.4–24406.4