Comparison of Pharmacokinetic Profiles of 14 Major Bioactive Components in Normal and Arthritic Model Rats after Oral Administration of Angelicae pubescentis Radix by UPLC-MS/MS

Table 3

Recovery and matrix effect of 14 compounds and ISs in rat plasma (n = 6).

Analytes	Concentration (ng/mL)	Recovery (%)	Matrix effect (%)
		Mean ± SD	Mean ± SD
Neochlorogenic acid	10	98.37 ± 0.84	96.03 ± 0.24
	252	98.53 ± 1.18	97.36 ± 0.83
	504	99.35 ± 0.56	96.67 ± 0.71
Chlorogenic acid	10.6	93.79 ± 4.36	96.75 ± 0.60
	1060	98.67 ± 1.81	99.66 ± 0.40
	3180	99.55 ± 2.08	100.19 ± 2.90
Cryptochlorogenic acid	11.7	96.62 ± 0.81	95.87 ± 1.31
	117	93.56 ± 2.76	92.87 ± 2.47
	234	97.11 ± 1.50	93.64 ± 5.02
3,4-diCQA	11.2	96.45 ± 2.84	94.87 ± 4.77
	56	100.55 ± 1.03	94.29 ± 3.61
	112	94.39 ± 2.53	98.10 ± 0.79
3,5-diCQA	12.5	100.24 ± 1.44	99.19 ± 0.76
	312.5	99.44 ± 0.34	98.73 ± 1.47
	625	96.17 ± 2.42	93.75 ± 1.53
4,5-diCQA	20.4	95.94 ± 5.51	94.74 ± 5.71
	102	90.38 ± 7.27	88.11 ± 5.31
	204	98.24 ± 2.58	96.54 ± 1.30
Columbianetin	39	100.61 ± 1.72	91.94 ± 9.71
	2260	94.77 ± 4.24	94.89 ± 4.41
	4520	99.57 ± 0.56	99.45 ± 0.71
Psoralen	5.05	93.25 ± 4.57	96.85 ± 0.22
	252.5	96.67 ± 6.07	98.33 ± 1.58
	505	99.16 ± 0.67	98.98 ± 0.53
Xanthotoxin	11.2	97.27 ± 1.08	98.69 ± 1.27
	560	97.90 ± 1.24	98.17 ± 0.99
	1120	95.60 ± 0.47	99.72 ± 0.11
Bergapten	13	94.7 ± 9.98	95.13 ± 9.57
	340	103.73 ± 2.78	92.19 ± 8.08
	680	100.62 ± 10.70	96.77 ± 8.80
Columbianetin acetate	54	95.58 ± 0.88	93.72 ± 6.68
	2160	98.04 ± 1.90	100.09 ± 7.76
	4320	100.06 ± 3.49	97.66 ± 3.34
Isoimperatorin	8.9	99.29 ± 2.11	99.81 ± 1.91
	445	95.01 ± 3.06	95.95 ± 2.76
	890	95.66 ± 5.42	90.78 ± 9.05
Osthol	5.5	94.26 ± 3.63	96.24 ± 0.79
	2200	99.93 ± 1.34	98.92 ± 2.45
	5500	100.16 ± 1.59	98.70 ± 0.70
Columbianadin	12.2	91.42 ± 3.26	94.17 ± 5.35
	1220	99.66 ± 1.20	99.85 ± 1.67
	2440	96.46 ± 9.48	102.29 ± 8.50
Chloramphenicol	100	96.68 ± 2.07	97.72 ± 3.17
Daidzein	100	99.74 ± 6.36	99.75 ± 1.89