Evidence-Based Complementary and Alternative Medicine / 2022 / Article / Tab 4 / Research Article
Comparison of Pharmacokinetic Profiles of 14 Major Bioactive Components in Normal and Arthritic Model Rats after Oral Administration of Angelicae pubescentis Radix by UPLC-MS/MS Table 4 The stability test of 14 compounds in rat plasma (n = 6).
Analytes Concentration (ng/mL) Short term stability Long term stability Freeze-thaw cycles stability Posttreatment stability RSD (%) RE (%) RSD (%) RE (%) RSD (%) RE (%) RSD (%) RE (%) Neochlorogenic acid 10 2.83 3.18 3.80 3.30 4.30 2.40 7.71 0.96 252 4.02 11.46 4.33 11.71 2.86 10.25 2.10 9.31 504 12.07 3.48 13.42 1.97 11.60 2.89 10.32 3.01 Chlorogenic acid 10.6 13.41 −10.70 11.16 −10.10 9.30 −9.38 7.04 −8.90 1060 0.57 −4.07 2.31 −3.00 0.96 −7.72 2.42 −2.64 3180 2.98 −12.94 5.95 −14.43 11.29 −14.56 8.15 −12.93 Cryptochlorogenic acid 11.7 4.62 0.09 7.81 0.11 4.91 0.10 2.47 0.05 117 5.89 2.98 5.10 2.57 4.78 2.12 3.40 2.21 234 7.76 3.55 8.13 1.12 6.02 0.54 5.95 0.37 3,4-diCQA 11.2 9.42 7.83 8.78 8.03 11.50 4.70 10.99 3.59 56 3.26 1.26 5.41 0.47 2.76 0.11 2.41 2.38 112 11.76 10.17 11.25 9.46 6.54 12.74 8.70 10.42 3,5-diCQA 12.5 2.91 10.66 7.37 5.53 2.47 11.59 6.67 2.20 312.5 7.18 −2.48 6.17 −3.61 5.56 −3.62 4.84 −3.41 625 2.51 1.54 2.33 1.49 2.15 1.58 1.80 1.31 4,5-diCQA 20.4 5.56 −0.05 5.22 −1.39 4.65 −1.10 4.61 −1.17 102 3.52 1.81 4.46 1.98 4.57 1.74 2.78 0.33 204 2.03 0.82 1.41 0.18 1.67 0.80 1.81 0.03 Columbianetin 39 5.28 0.47 4.79 8.79 1.88 −5.49 2.58 7.89 2260 3.07 4.19 2.27 3.56 1.39 3.82 1.55 3.59 4520 1.27 −0.87 1.18 −0.94 0.98 −0.84 0.86 −0.88 Psoralen 5.05 5.69 −5.85 3.17 −8.84 10.07 −8.37 1.57 −13.10 252.5 3.86 7.43 5.16 9.22 0.45 11.50 1.70 5.27 505 5.47 7.62 4.56 5.91 0.93 10.13 2.53 8.21 Xanthotoxin 11.2 9.77 0.18 9.36 −0.74 7.04 0.06 7.03 −0.52 560 2.68 −0.81 2.57 −0.76 2.16 −0.74 1.97 −1.16 1120 2.36 7.30 2.76 7.34 4.24 6.75 4.79 1.28 Bergapten 13 6.95 0.63 7.66 1.53 7.64 2.72 8.44 1.62 340 9.35 −13.21 6.41 −12.79 6.19 −7.04 3.46 −10.30 680 7.50 5.28 4.17 1.84 7.17 4.19 6.40 7.29 Columbianetin acetate 54 8.01 0.55 7.18 2.56 7.42 1.77 2.03 1.96 2160 7.73 7.96 5.53 3.76 6.37 9.80 0.25 6.87 4320 3.35 2.64 1.90 3.38 4.58 4.44 4.29 4.02 Isoimperatorin 8.9 2.74 1.35 4.79 0.03 3.83 1.05 1.78 0.78 445 2.83 −12.34 3.49 −12.65 4.33 −13.11 5.87 −13.01 890 2.60 0.18 6.96 0.87 4.10 0.53 3.37 1.16 Osthol 5.5 0.73 3.44 6.79 -0.08 4.39 −3.84 3.64 −3.39 2200 4.19 0.28 8.56 0.09 2.82 0.81 4.34 1.27 5500 2.27 0.82 4.58 0.53 5.89 1.74 2.70 5.18 Columbianadin 12.2 14.15 −2.01 12.98 −1.51 14.63 −8.53 13.80 −6.29 1220 7.48 2.07 7.02 1.08 8.37 −0.74 6.79 0.72 2440 9.13 −5.05 6.13 −2.67 8.24 −0.12 9.69 −2.46