Research Article

Comparison of Pharmacokinetic Profiles of 14 Major Bioactive Components in Normal and Arthritic Model Rats after Oral Administration of Angelicae pubescentis Radix by UPLC-MS/MS

Table 4

The stability test of 14 compounds in rat plasma (n = 6).

AnalytesConcentration (ng/mL)Short term stabilityLong term stabilityFreeze-thaw cycles stabilityPosttreatment stability
RSD (%)RE (%)RSD (%)RE (%)RSD (%)RE (%)RSD (%)RE (%)

Neochlorogenic acid102.833.183.803.304.302.407.710.96
2524.0211.464.3311.712.8610.252.109.31
50412.073.4813.421.9711.602.8910.323.01

Chlorogenic acid10.613.41−10.7011.16−10.109.30−9.387.04−8.90
10600.57−4.072.31−3.000.96−7.722.42−2.64
31802.98−12.945.95−14.4311.29−14.568.15−12.93

Cryptochlorogenic acid11.74.620.097.810.114.910.102.470.05
1175.892.985.102.574.782.123.402.21
2347.763.558.131.126.020.545.950.37

3,4-diCQA11.29.427.838.788.0311.504.7010.993.59
563.261.265.410.472.760.112.412.38
11211.7610.1711.259.466.5412.748.7010.42

3,5-diCQA12.52.9110.667.375.532.4711.596.672.20
312.57.18−2.486.17−3.615.56−3.624.84−3.41
6252.511.542.331.492.151.581.801.31

4,5-diCQA20.45.56−0.055.22−1.394.65−1.104.61−1.17
1023.521.814.461.984.571.742.780.33
2042.030.821.410.181.670.801.810.03

Columbianetin395.280.474.798.791.88−5.492.587.89
22603.074.192.273.561.393.821.553.59
45201.27−0.871.18−0.940.98−0.840.86−0.88

Psoralen5.055.69−5.853.17−8.8410.07−8.371.57−13.10
252.53.867.435.169.220.4511.501.705.27
5055.477.624.565.910.9310.132.538.21

Xanthotoxin11.29.770.189.36−0.747.040.067.03−0.52
5602.68−0.812.57−0.762.16−0.741.97−1.16
11202.367.302.767.344.246.754.791.28

Bergapten136.950.637.661.537.642.728.441.62
3409.35−13.216.41−12.796.19−7.043.46−10.30
6807.505.284.171.847.174.196.407.29

Columbianetin acetate548.010.557.182.567.421.772.031.96
21607.737.965.533.766.379.800.256.87
43203.352.641.903.384.584.444.294.02

Isoimperatorin8.92.741.354.790.033.831.051.780.78
4452.83−12.343.49−12.654.33−13.115.87−13.01
8902.600.186.960.874.100.533.371.16

Osthol5.50.733.446.79-0.084.39−3.843.64−3.39
22004.190.288.560.092.820.814.341.27
55002.270.824.580.535.891.742.705.18

Columbianadin12.214.15−2.0112.98−1.5114.63−8.5313.80−6.29
12207.482.077.021.088.37−0.746.790.72
24409.13−5.056.13−2.678.24−0.129.69−2.46