Comparison of Pharmacokinetic Profiles of 14 Major Bioactive Components in Normal and Arthritic Model Rats after Oral Administration of Angelicae pubescentis Radix by UPLC-MS/MS

Table 5

The main pharmacokinetic parameters of 15 compounds in normal and arthritic model rat groups after oral administration of APR (mean ± SD, n = 6).

Analytes	Group	AUC0-t (ng/Lh)	AUC0-∞ (ng/Lh)	Cmax (ng/mL)	tmax (h)	t1/2 (h)	MRT0-t (h)	CL (L/h/kg)
Neochlorogenic acid	Normal	1140.97 ± 76.91	1841.89 ± 375.29	419.76 ± 58.64	0.20 ± 0.04	39.94 ± 16.54	15.59 ± 0.68	16.79 ± 3.08
	Model	1191.17 ± 45.24	1730.83 ± 234.76	531.12 ± 24.05	0.23 ± 0.03	31.80 ± 10.17	15.60 ± 0.26	17.56 ± 2.06
Chlorogenic acid	Normal	3750.55 ± 258.95	5361.78 ± 591.80	1669.61 ± 25.80	0.54 ± 0.36	27.89 ± 14.85	5.95 ± 0.28	5.64 ± 0.56
	Model	4518.22 ± 123.41	5658.96 ± 1752.92	2759.25 ± 264.26	0.45 ± 0.10	51.97 ± 13.17	8.68 ± 0.52	5.67 ± 1.47
Cryptochlorogenic acid	Normal	1293.94 ± 31.4	2023.36 ± 571.79	142.61 ± 4.63	0.42 ± 0.12	34.55 ± 17.65	18.26 ± 0.46	15.70 ± 3.89
	Model	1695.03 ± 117.262	3849.34 ± 472.22	188.64 ± 8.70	0.45 ± 0.10	48.36 ± 10.53	19.51 ± 0.55	7.89 ± 1.02
3,4-diCQA	Normal	664.51 ± 54.19	1472.35 ± 280.50	85.71 ± 8.14	0.29 ± 0.10	57.97 ± 11.96	21.16 ± 0.73	21.06 ± 4.38
	Model	504.41 ± 19.59	1744.69 ± 748.99	79.74 ± 7.11	0.29 ± 0.10	84.47 ± 24.30	19.81 ± 0.40	19.66 ± 7.70
3,5-diCQA	Normal	1129.67 ± 137.54	1762.50 ± 613.93	292.78 ± 47.74	0.18 ± 0.03	33.90 ± 14.30	21.07 ± 0.68	18.37 ± 4.81
	Model	961.07 ± 40.95	3223.71 ± 110.12	405.33 ± 49.16	0.18 ± 0.03	59.48 ± 17.24	18.79 ± 0.49	10.62 ± 4.85
4,5-diCQA	Normal	1011.06 ± 30.37	2283.82 ± 375.11	125.50 ± 11.99	0.24 ± 0.03	52.82 ± 19.30	21.70 ± 0.72	11.34 ± 6.62
	Model	760.23 ± 40.08	1287.79 ± 198.07	154.10 ± 8.92	0.23 ± 0.03	40.72 ± 5.72	21.72 ± 0.78	11.76 ± 9.60
Columbianetin	Normal	30285.36 ± 1540.07	30618.34 ± 1524.53	3116.03 ± 241.95	9.67 ± 0.82	6.04 ± 0.12	13.30 ± 0.36	0.98 ± 0.05
	Model	25928.65 ± 675.38	26123.62 ± 692.36	2220.70 ± 167.90	9.00 ± 1.09	6.07 ± 1.28	12.10 ± 0.20	1.14 ± 0.03
Psoralen	Normal	3231.02 ± 159.33	3431.94 ± 240.22	209.65 ± 27.61	8.00 ± 1.26	9.80 ± 3.28	14.34 ± 0.31	8.77 ± 0.59
	Model	3745.47 ± 90.89	3770.10 ± 922.58	326.62 ± 42.49	7.66 ± 0.81	5.98 ± 0.44	12.93 ± 0.22	7.96 ± 019
Xanthotoxin	Normal	4443.85 ± 187.58	4619.69 ± 224.28	553.93 ± 76.03	4.33 ± 0.82	12.12 ± 1.73	10.72 ± 0.53	6.50 ± 0.31
	Model	4637.98 ± 148.45	4887.81 ± 179.48	528.00 ± 34.98	3.33 ± 1.03	14.25 ± 3.76	10.30 ± 0.51	6.14 ± 0.22
Bergapten	Normal	2263.69 ± 175.96	2331.37 ± 183.83	383.01 ± 95.75	3.67 ± 0.82	9.41 ± 2.12	9.40 ± 0.34	12.93 ± 1.05
	Model	3119.18 ± 100.34	3185.02 ± 140.89	518.44 ± 42.86	4.67 ± 1.03	7.16 ± 0.41	7.11 ± 0.09	9.43 ± 0.42
Columbianetin acetate	Normal	9066.10 ± 950.05	10092.04 ± 1428.28	2020.33 ± 162.24	0.18 ± 0.03	17.30 ± 3.61	18.56 ± 0.64	2.61 ± 1.06
	Model	9190.51 ± 376.09	10597.06 ± 389.11	2243.01 ± 304.11	0.15 ± 0.03	15.92 ± 2.06	15.83 ± 0.91	2.83 ± 0.10
Isoimperatorin	Normal	1188.60 ± 68.55	1555.48 ± 149.22	224.37 ± 26.80	0.58 ± 0.20	26.91 ± 8.34	15.10 ± 0.57	19.42 ± 1.73
	Model	1277.40 ± 36.97	1653.04 ± 86.14	232.11 ± 20.96	0.58 ± 0.20	26.76 ± 5.46	15.71 ± 0.65	18.18 ± 0.88
Osthol	Normal	11448.25 ± 552.50	11648.88 ± 567.74	3642.21 ± 286.50	1.16 ± 0.40	13.42 ± 0.51	6.53 ± 0.29	2.58 ± 0.11
	Model	22518.30 ± 2167.96	22544.07 ± 2169.73	4561.27 ± 271.63	0.91 ± 0.20	6.42 ± 0.69	6.94 ± 0.42	1.33 ± 0.11
Columbianadin	Normal	2661.55 ± 122.95	2968.16 ± 200.66	1683.74 ± 221.50	0.23 ± 0.03	16.43 ± 3.96	12.30 ± 0.57	10.14 ± 0.70
	Model	3487.92 ± 132.71	3849.07 ± 265.00	1497.02 ± 48.21	0.23 ± 0.03	16.51 ± 4.83	11.51 ± 0.87	7.82 ± 0.51

and compared with the normal group.