Validation of Antidiabetic and Antihyperlipidemic Effects of 80% Methanolic Extract of the Lonchocarpus laxiflorus Leaves in Streptozotocin-Induced Diabetic Swiss Albino Mice

Table 3

The effect of the crude extract on oral glucose loaded mice.

Blood glucose level (mg/dl) at different time intervals
Dose (mg/kg)	0 h	0.5 h	1 h	2 h
NC	87.39 ± 2.07	164.00 ± 0.95	158.48 ± 1.93	153.03 ± 3.33
CE 100	92.59 ± 1.46	161.04 ± 1.40	151.38 ± 1.74	1487.51 ± 2.07
CE 200	94.28 ± 1.13	149.92 ± 2.48^a2	135.18 ± 2.08^a3β3	105.86 ± 2.27^a3b2β3
CE 400	92.80 ± 1.87	142.66 ± 1.77^a3b3c2	105.47 ± 3.89^a3b3β3	93.99 ± 1.30^a3b3c1β3
GLC 5	89.62 ± 1.92	138.40 ± 1.20^a3b3c2	100.62 ± 4.21^a3b1β3	89.82 ± 2.17^a3b3c3β3

Each value represents as mean ± SEM; n = 6 for each treatment. ^aCompared to the negative control, ^bcompared to 100 mg/kg, ^ccompared to 200 mg/kg, ^βcompared to baseline blood glucose level. ¹ < 0.05, ² < 0.01, and ³ < 0.001. NC = negative control received 2% Tween in distilled water, and GLC = glibenclamide, CE = crude extract.