The Hair Growth-Promoting Effect of Gardenia florida Fruit Extract and Its Molecular Regulation

Figure 4

Hair growth-stimulating effect of GFFE in an in vivo C57BL/6 male mice model. Mice were shaved on postnatal day 44 and topically treated with NC or GFFE (dissolved in water at 0.5%, 1.0%, and 2.0% final) every day over 30 days. Photographs shown were taken on day 0, 7, 14, 21, and 30 after treatment. Indicative of anagen induction by the treatment, melanin pigmentation in the skin of GFFE-treated animals became visible as early as day 7; NC mice did not show significant pigmentation for at least 21 days. However, all mice in NC, GFFE, or Minoxidil treatments exhibited almost overall hair growth on day 30.