Toxicological Safety Evaluation in Acute and 21-Day Studies of Ethanol Extract from Solanum lyratum Thunb

Table 1

Effect of the ESL, mg/kg i.g., on relative weights of the internal organs of mice after 21 days of treatment.

Relative organ weights	Control	180 mg/kg	360 mg/kg	720 mg/kg
Brain	1.17 ± 0.03	1.32 ± 0.07	1.21 ± 0.04	1.26 ± 0.02
Liver	4.58 ± 0.12	4.32 ± 0.13	4.43 ± 0.19	4.67 ± 0.31
Spleen	0.29 ± 0.03	0.28 ± 0.02	0.28 ± 0.02	0.30 ± 0.11
Right kidney	0.88 ± 0.03	0.92 ± 0.03	0.81 ± 0.04	0.86 ± 0.04
Left kidney	0.83 ± 0.04	0.88 ± 0.04	0.74 ± 0.05	0.80 ± 0.05
Lung	0.59 ± 0.03	0.70 ± 0.04	0.67 ± 0.03	0.69 ± 0.02
Heart	0.58 ± 0.03	0.63 ± 0.03	0.56 ± 0.03	0.65 ± 0.03
Stomach	1.10 ± 0.08	1.13 ± 0.05	1.34 ± 0.08	1.26 ± 0.04

vs. control group. Relative organ weights in %; the values represent mean ± S.E.M. for 6 animals/group. One way ANOVA, followed by Dunnett’s post hoc test.