Research Article
Toxicological Safety Evaluation in Acute and 21-Day Studies of Ethanol Extract from Solanum lyratum Thunb
Table 2
Effect of the ESL, mg/kg i.g., on hematologic parameters in mice.
| Haematologic parameters | Control (0 mg/kg) | 180 mg/kg | 360 mg/kg | 720 mg/kg |
| WBC (10^9/L) | 7.67 ± 1.88 | 7.61 ± 0.93 | 8.28 ± 2.22 | 8.09 ± 0.90 | RBC (10^12/L) | 7.95 ± 0.37 | 8.22 ± 0.27 | 7.82 ± 0.29 | 7.60 ± 0.22 | PLT (10^9/L) | 858.8 ± 111.55 | 884.60 ± 81.80 | 885.5 ± 27.38 | 842.45 ± 83.09 | HB (g/dL) | 14.75 ± 0.45 | 16.83 ± 0.93 | 14.36 ± 0.34 | 13.94 ± 0.57 | HCT (%) | 49.37 ± 2.02 | 49.79 ± 1.90 | 45.07 ± 1.30 | 47.50 ± 1.77 | MCV (fL) | 62.17 ± 0.74 | 61.18 ± 2.00 | 60.22 ± 1.04 | 61.73 ± 1.59 | MCH (pg) | 19.05 ± 0.30 | 19.32 ± 0.50 | 18.88 ± 0.39 | 19.30 ± 0.58 | MCHC (g/dL) | 30.69 ± 0.33 | 31.09 ± 0.27 | 31.5 ± 0.51 | 30.73 ± 0.32 | Neutrophils (%) | 18.53 ± 1.58 | 18.94 ± 3.12 | 20.17 ± 2.02 | 23.80 ± 3.69 | Lymphocytes (%) | 74.83 ± 2.51 | 75.07 ± 1.63 | 73.85 ± 1.61 | 69.00 ± 3.10 |
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vs. control group. The values represent mean ± S.E.M. for 6 animals/group. One way ANOVA, followed by Dunnett’s post hoc test. |