Toxicological Safety Evaluation in Acute and 21-Day Studies of Ethanol Extract from Solanum lyratum Thunb

Table 3

Effect of the ESL, mg/kg i.g., on biochemical parameters in mice.

Biochemical parameters	Control	180 mg/kg	360 mg/kg	720 mg/kg
Total protein (g/l)	53.53 ± 2.78	56.68 ± 1.49	57.78 ± 1.92	58.83 ± 1.82
Albumin (g/l)	31.78 ± 2.35	34.08 ± 0.48	35.40 ± 1.10	34.10 ± 0.82
Globulin (g/l)	21.75 ± 0.91	22.60 ± 1.19	22.38 ± 0.83	24.73 ± 2.27
Total bilirubin (umol/l)	1.15 ± 0.95	1.18 ± 0.23	1.20 ± 0.82	1.20 ± 0.58
Alanine transaminase (u/l)	36.25 ± 2.02	34.25 ± 6.61	36.00 ± 10.89	37.25 ± 5.50
Aspertate aminotransferase (u/l)	49.50 ± 5.92	52.75 ± 5.85	57.75 ± 8.07	51.50 ± 9.19
Alkaline phosphatase (u/l)	73.75 ± 4.89	72.50 ± 5.33	74.00 ± 5.42	73.00 ± 10.56
Total cholesterol (mmol/l)	3.41 ± 0.49	3.50 ± 0.38	3.51 ± 0.41	3.36 ± 0.53
Glucose (mmol/l)	5.64 ± 1.52	5.67 ± 0.51	5.55 ± 0.72	5.60 ± 0.62
Urea nitrogen (mmol/l)	5.28 ± 0.57	8.41 ± 0.94	6.13 ± 0.62	5.46 ± 0.35
Creatinine (umol/l)	17.58 ± 4.75	17.85 ± 3.45	17.70 ± 4.57	17.43 ± 3.32

vs. control group. The values represent mean ± S.E.M. for 6 animals/group. One way ANOVA, followed by Dunnett’s post hoc test.