Combination Therapy with TCM Preparation Kumu Injection and Azithromycin against Bacterial Infection and Inflammation: In Vitro and In Vivo

Table 1

MIC and FICI of AZM with KM against common bacterial strains.

Strain	Alone MIC (mg/L)		Com MIC (mg/L)		FICI	Outcome^∗
	AZM	KM	AZM	KM
Standard strains
S. aureus	2	1	0.5	0.06	0.31	1
E. coli	8	0.5	2	0.03	0.31	1
H. streptococcus	2	0.25	1	0.06	0.74	2
K. pneumoniae	2	0.25	0.25	0.06	0.37	1
S. pneumoniae	1	0.5	0.25	0.12	0.49	1
S. dysenteriae	2	1	0.5	0.12	0.37	1
P. aeruginosa	4	2	4	2	2	3
Resistant strains
S. aureus	256	1	32	0.25	0.38	1
E. coli	256	0.5	64	0.125	0.5	1
K. pneumoniae	256	0.25	32	0.06	0.37	1
S. pneumoniae	256	0.5	64	0.125	0.5	1
S. dysenteriae	256	1	64	0.125	0.8	1

Note: ^∗1 stood for synergy with FICI ≤0.5, 2 for additive with FICI ranging between 0.5 and 1, and 3 for indifference FICI ranging between 1 and 2.