Combination Therapy with TCM Preparation Kumu Injection and Azithromycin against Bacterial Infection and Inflammation: In Vitro and In Vivo

Table 3

Pharmacokinetic parameters for AZM in rats i.v. administered multidose of AZM with or without an equivalent dose of KM (both 75.0 mg/kg once daily for 7 days).

Parameters	AZM alone	KM + AZM
AUC0-t (μg/L·h)	7813.66 ± 1120.12	6274.32 ± 3170.05
MRT0-t (h)	4.93 ± 0.40	8.38 ± 0.32
t1/2 (h)	7.54 ± 2.76	9.12 ± 2.97
CL (L/h/kg)	8.80 ± 1.71	7.55 ± 5.29
Vd (L/kg)	92.83 ± 23.68	150.95 ± 34.64

indicated a significant difference from the AZM alone.