Renoprotective and Cardioprotective Potential of Moricandia sinaica (Boiss.) against Carbon Tetrachloride-Induced Toxicity in Rats
Table 1
Effect of extracts on Cardiac function test treated with CCl4.
Treatments
Dose (mg/kg0)
Creatine-kinase (mg/dl)
LDH (mg/dl)
Mean ± S.E
(%) change
Mean ± S.E
(%) change
Normal
208.33 ± 3.91
96.86 ± 3.77
CCl4
401.50 ± 7.01
93↑
190.03 ± 8.89
96↑
Silymarin + CCl4
10
234.83 ± 3.74
42↓
119.60 ± 3.73
37↓
MOR-1 + CCl4
100
399.50 ± 4.51
186.37 ± 5.21
MOR-1 + CCl4
200
381.00 ± 4.69
5↓
168.81 ± 4.70
11↓
MOR-2 + CCl4
100
328.66 ± 13.81
18↓
137.45 ± 4.85
28↓
MOR-2 + CCl4
200
269.83 ± 7.50
32.79↓
127.61 ± 3.60
33↓
MOR-3 + CCl4
100
418.16 ± 14.96
4↑
194.95 ± 5.54
MOR-3 + CCl4
200
429.00 ± 7.18
7↑
180.50 ± 7.84
5↑
All values represent mean ± SEM. ;; ANOVA, followed by Dunnett's multiple comparison test. 1-CCl4 group compared to the normal group, 2-Treated groups compared with the CCl4 group. Bold values are the quantity of dose in mg/kg.
