Supplementation with the Traditional Thai Polyherbal Medicine NawaTab Ameliorates Lipid Profiles in High-Fat Diet-Induced Hyperlipidemic Rats

Table 2

Effect of NawaTab on serum lipid profiles, the relative weight of adipose tissue, hepatic steatosis, fecal lipid excretion, and lipase activity of high-fat diet (HFD)-induced hyperlipidemic rats.

Parameters	Control	HFD
		Vehicle	NawaTab	Simvastatin
			(125 mg/kg/day)	(10 mg/kg/day)
TC (mg/dL)	57.3 ± 2.8^a	105.7 ± 9.4^b	79.8 ± 3.3^c	82.2 ± 2.8^c
TG (mg/dL)	112.0 ± 13.1^a,b	149.0 ± 19.2^b	77.7 ± 12.7^a	109.2 ± 12.1^a,b
HDL-C (mg/dL)	22.3 ± 1.4^a	29.0 ± 1.9^b	24.5 ± 0.7^a,b	23.8 ± 0.6^a
LDL-C (mg/dL)	3.3 ± 0.3^a	8.0 ± 0.8^b	5.8 ± 0.3^c	6.0 ± 0.4^c
VLDL-C (mg/dL)	22.3 ± 2.6^a,b	29.7 ± 3.9^b	15.5 ± 2.5^a	21.8 ± 2.4^a,b
Relative weight of adipose tissues (%)
(i) Retroperitoneal adipose tissue	3.64 ± 0.13^a	5.23 ± 0.21^b	5.04 ± 0.28^b	5.40 ± 0.30^b
(ii) Mesenteric adipose tissue	2.36 ± 0.07^a	3.66 ± 0.14^b	3.17 ± 0.17^b	3.35 ± 0.29^b
(iii) Epididymal adipose tissue	2.62 ± 0.12^a	3.99 ± 0.18^b	4.09 ± 0.25^b	4.20 ± 0.27^b
(iv) Subcutaneous adipose tissue	2.40 ± 0.17^a	3.84 ± 0.36^b	3.11 ± 0.21^a,b	3.66 ± 0.40^b
(v) Brown adipose tissue	0.07 ± 0.01^a	0.08 ± 0.01^a,b	0.11 ± 0.01^b	0.11 ± 0.01^b
Hepatic steatosis (%)	2.8 ± 1.3^a	92.4 ± 3.9^b	86.4 ± 4.0^b	13.0 ± 2.8^c
Fecal lipid (mg/g)	66.27 ± 2.87^a	51.00 ± 1.34^b	42.40 ± 0.51^b	45.00 ± 3.85^b
Lipase (U/L)	4.00 ± 0.63^a	9.67 ± 1.12^b	8.83 ± 1.74^b	6.00 ± 0.68^a,b

The results are given as means ± SEM (n = 6). Values in the same row sharing a common superscript are not significantly different (). TC, total cholesterol; TG, triglyceride; HDL-C, high-density lipoprotein cholesterol; LDL-C, low-density lipoprotein cholesterol; VLDL-C, very low-density lipoprotein cholesterol.