Supplementation with the Traditional Thai Polyherbal Medicine NawaTab Ameliorates Lipid Profiles in High-Fat Diet-Induced Hyperlipidemic Rats

Table 3

Effect of NawaTab on the relative weight of organs and biochemical and hematological parameters of high-fat diet (HFD)-induced hyperlipidemic rats.

Parameters	Control	HFD
		Vehicle	NawaTab	Simvastatin
			(125 mg/kg/day)	(10 mg/kg/day)
Relative weight of organs (%)
Heart	0.24 ± 0.01^a	0.22 ± 0.01^a	0.22 ± 0.01^a	0.22 ± 0.00^a
Liver	2.75 ± 0.13^a	2.62 ± 0.08^a	2.47 ± 0.07^a	2.48 ± 0.08^a
Kidney	0.56 ± 0.02^a	0.45 ± 0.01^b	0.49 ± 0.01^b	0.48 ± 0.01^b
Spleen	0.16 ± 0.00^a	0.14 ± 0.01^a	0.16 ± 0.01^a	0.14 ± 0.01^a
Biochemical parameters
Alkaline phosphatase (U/L)	70.5 ± 5.4^a	87.3 ± 5.8^a	80.0 ± 7.9^a	82.7 ± 7.8^a
Alanine aminotransferase (U/L)	33.0 ± 3.5^a	41.0 ± 8.4^a	35.0 ± 3.5^a	30.8 ± 2.7^a
Aspartate aminotransferase (U/L)	103.0 ± 10.1^a	126.2 ± 7.5^a	124.0 ± 4.1^a	131.2 ± 17.2^a
Total bilirubin (mg/dL)	0.15 ± 0.0^a	0.20 ± 0.00^a	0.22 ± 0.02^a	0.20 ± 0.00^a
Direct bilirubin (mg/dL)	0.10 ± 0.00^a	0.10 ± 0.00^a	0.10 ± 0.00^a	<0.10^a
Total protein (g/dL)	5.70 ± 0.07^a	5.93 ± 0.08^a	5.80 ± 0.11^a	5.77 ± 0.08^a
Globulin (g/dL)	2.90 ± 0.05^a	2.95 ± 0.03^a	2.90 ± 0.08^a	2.88 ± 0.05^a
Albumin (g/dL)	2.80 ± 0.03^a	2.98 ± 0.22^a	2.90 ± 0.07^a	2.88 ± 0.13^a
Blood urea nitrogen (mg/dL)	19.5 ± 0.5^a	17.8 ± 0.5^a	16.3 ± 0.9^a	17.8 ± 1.1^a
Creatinine (mg/dL)	0.46 ± 0.06^a	0.39 ± 0.02^a	0.41 ± 0.02^a	0.34 ± 0.01^a
Hematological parameters
WBC (10^3/mL)	3.18 ± 0.24^a	3.49 ± 0.44^a	4.43 ± 0.73^a	3.78 ± 0.69^a
Neutrophils (%)	7.52 ± 1.36^a	3.48 ± 0.53^a	7.47 ± 2.37^a	9.20 ± 2.17^a
Lymphocytes (%)	54.00 ± 6.24^a	76.58 ± 2.64^b	78.03 ± 1.55^b	78.25 ± 2.33^b
Monocytes (%)	35.27 ± 5.81^a	17.52 ± 2.16^b	13.30 ± 1.53^b	10.98 ± 1.31^b
Eosinophils (%)	2.68 ± 0.34^a	2.13 ± 0.54^a,b	0.95 ± 0.37^b	1.55 ± 0.42^a,b
Basophils (%)	0.53 ± 0.11^a	0.28 ± 0.05^a,b	0.25 ± 0.18^a,b	0.02 ± 0.02^b
RBC (10^6/mL)	8.74 ± 0.12^a	8.26 ± 0.20^a	8.37 ± 0.21^a	8.62 ± 0.16^a
Hemoglobin (g/dL)	15.58 ± 0.32^a	15.00 ± 0.40^a	15.47 ± 0.26^a	15.27 ± 0.27^a
Hematocrit (%)	48.83 ± 0.98^a	46.45 ± 1.45^a	47.60 ± 0.83^a	47.60 ± 0.69^a
Platelet count (10^3/mL)	719.5 ± 30.6^a	660.3 ± 22.8^a	683.2 ± 25.4^a	644.8 ± 24.9^a
MCV (fL)	55.83 ± 0.43^a	56.20 ± 0.51^a	56.93 ± 0.62^a	55.30 ± 0.68^a
MCH (pg)	17.82 ± 0.15^a	18.17 ± 0.11^a,b	18.50 ± 0.18^b	17.73 ± 0.23^a
MCHC (g/dL)	31.92 ± 0.20^a	32.32 ± 0.17^a	32.50 ± 0.19^a	32.08 ± 0.23^a
RDW (%)	12.55 ± 0.21^a	12.57 ± 0.37^a	12.38 ± 0.15^a	12.70 ± 0.16^a

The results are given as means ± SEM (n = 6). Values in the same row sharing a common superscript are not significantly different (). WBC, white blood cells; RBC, red blood cells; MCV, mean corpuscular volume; MCH, mean corpuscular hemoglobin; MCHC, mean corpuscular hemoglobin concentration; RDW, red cell distribution width.