Tetrandrine Ameliorates Rheumatoid Arthritis in Mice by Alleviating Neutrophil Activities

<div>The effect of TET on NETs formation <i>in vitro</i>. After stimulation with PMA for 5 h, neutrophils were stained with DAPI (blue) and anti-NE antibody (red) to visualize NETs using confocal microscopy. (a) NETs were formed after PMA stimulation. TET inhibited the NETs formation. (b) Nuclear areas were quantified and analyzed. Tetrandrine decreased the enlargement of the nuclear areas induced by PMA. 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602 238 602Z"></path></g><g transform="matrix(.013,0,0,-0.013,54.874,0)"><path d="M384 0V27C293 34 287 42 287 114V635C232 613 172 594 109 583V559L157 557C201 555 205 550 205 499V114C205 42 199 34 109 27V0H384Z"></path></g></svg> compared with the PMA group.</div>

Evidence-Based Complementary and Alternative Medicine

fig7

Figure 7

Figure 7: Tetrandrine Ameliorates Rheumatoid Arthritis in Mice by Alleviating Neutrophil Activities 