Research Article
Hydroalcoholic Extract of Sechium edule Fruits Attenuates QT Prolongation in High Fat Diet-Induced Hyperlipidemic Mice
Table 2
Effect on S.E. extracts on ECG parameters in HFD-induced hyperlipidemic mice.
| | Treatment | QT interval (ms) | QTc interval (ms) | RR interval (ms) | Heart rate (bpm) |
| | Normal control | 118.24 ± 0.37 | 10.22 ± 0.39 | 133.83 ± 0.58 | 448.64 ± 1.85 | | HFD control | 213.62 ± 2.10 | 14.15 ± 0.56 | 227.65 ± 1.16 | 260.46 ± 1.57 | | HFD + atorvastatin (10 mg/kg) | 168.43 ± 1.16 | 12.26 ± 0.65 | 188.64 ± 1.24 | 316.04 ± 1.00 | | HFD + S.E. extract (200 mg/kg) | 138.24 ± 1.02 | 10.97 ± 0.82 | 158.62 ± 1.03 | 370.30 ± 1.66 | | HFD + S.E. extract (400 mg/kg) | 127.68 ± 1.32 | 10.19 ± 0.30 | 156.89 ± 0.91 | 393.15 ± 2.20 |
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n = 6, data are expressed in Mean ± SEM. , HDF control vs. normal control. , treatment groups vs. HDF control. |
