Systematic Elaboration of the Pharmacological Targets and Potential Mechanisms of ZhiKe GanCao Decoction for Preventing and Delaying Intervertebral Disc Degeneration

Table 2

Basic information of 11 active components in ZKGCD.

Molecule ID	Molecule name	PubChem CID	OB (%)	DL	Source (herb name)	Targeted key genes
MOL000098	Quercetin	5280343	46.43	0.28	GanCao	AKT1, MMP9, TNF, JUN, IL6, CASP3, TP53, IL1B
MOL000006	Luteolin	5280445	36.16	0.25	DanShen	AKT1, MMP9, TNF, JUN, IL6, CASP3, TP53
MOL000422	Kaempferol	5280863	41.88	0.24	GanCao	AKT1, TNF, JUN, CASP3
MOL004328	Naringenin	932	59.29	0.21	ZhiKe, GanCao	AKT1, MAPK3, CASP3
MOL000392	Formononetin	5280378	69.67	0.21	GanCao, SanLeng	JUN
MOL005828	Nobiletin	72344	61.67	0.52	ZhiKe	MMP9, JUN, TP53
MOL007154	Tanshinone IIA	164676	49.89	0.40	DanShen	MMP9, JUN, CASP3, TP53
MOL000497	Licochalcone A	5318998	40.79	0.29	GanCao	STAT3
MOL000354	Isorhamnetin	5281654	49.60	0.31	GanCao	/
MOL004373	Anhydroicaritin	44259058	45.41	0.44	QianNiuZi	/