Systematic Elaboration of the Pharmacological Targets and Potential Mechanisms of ZhiKe GanCao Decoction for Preventing and Delaying Intervertebral Disc Degeneration

Table 3

Cluster information of the protein-protein interaction (PPI) network for common genes.

Cluster	Score	Nodes	Edges	Gene names
1	50.156	65	1605	MMP2, TGFB1, SERPINE1, MPO, CCL2, CDK4, MYC, IL2, MDM2, IFNG, IL4, NR3C1, CRP, CDK2, MAPK3, IL1A, STAT3, ICAM1, TP53, VCAM1, NOS3, MMP3, BCL2L1, CXCL8, SELE, CXCL10, JUN, MMP9, MMP1, EDN1, SPP1, NOS2, MAPK8, CASP9, HSP90AA1, SIRT1, IKBKB, HIF1A, PPARG, ESR1, IL10, CASP8, STAT1, PTEN, EGFR, PPARA, ADIPOQ, MCL1, AKT1, CHUK, IL1B, FOS, NFKBIA, PTGS2, NFE2L2, CREB1, TNF, CCND1, CASP3, RELA, IL6, MAPK14, CDKN1A, HMOX1, TIMP1
2	7	19	63	NCF1, HSPB1, RAF1, AR, F3, PLAU, CCNB1, BIRC5, MAPK1, GSK3B, CAV1, CDK1, KDR, PRKCA, RB1, RUNX2, CCNA2, CASP7, HSPA5
3	3	3	3	F2, THBD, PLAT

Core genes are highlighted in red.