Research Article

Network Pharmacology and Experimental Verification Revealed the Mechanism of Yiqi Jianpi Recipe on Chronic Obstructive Pulmonary Disease

Table 3

Top 20 biological processes of core genes’ enrichment based on GO analysis.

IdDescription. adjustgeneID

GO: 0050673Epithelial cell proliferation1.81E-11AKT1/IL-6/VEGFA/ESR1/EGFR/MYC/HIF1A/PPARG/EGF/CCND1/ERBB2/CCL2
GO: 0042063Gliogenesis2.93E-10AKT1/IL-6/IL-1B/EGFR/MAPK3/STAT3/PPARG/ERBB2/CREB1/CCL2
GO: 0062197Cellular response to chemical stress1.03E-09AKT1/IL-6/JUN/CASP3/EGFR/HIF1A/MAPK3/MMP9/PPARG/FOS
GO: 0010038Response to metal ion1.03E-09AKT1/JUN/CASP3/EGFR/HIF1A/MAPK3/MMP9/FOS/CCND1/CREB1
GO: 0050678Regulation of epithelial cell proliferation1.34E-09AKT1/VEGFA/EGFR/MYC/HIF1A/PPARG/EGF/CCND1/ERBB2/CCL2
GO: 0048732Gland development2.50E-09AKT1/IL-6/VEGFA/ESR1/EGFR/HIF1A/MAPK3/EGF/CCND1/CREB1
GO: 0030099Myeloid cell differentiation2.62E-09JUN/VEGFA/CASP3/MYC/HIF1A/STAT3/MMP9/PPARG/FOS/CREB1
GO: 0006979Response to oxidative stress3.90E-09AKT1/IL-6/JUN/CASP3/PTGS2/EGFR/HIF1A/MAPK3/MMP9/FOS
GO: 0051090Regulation of DNA-binding transcription factor activity3.90E-09AKT1/IL-6/JUN/VEGFA/IL-1B/ESR1/MAPK3/STAT3/PPARG/FOS
GO: 0009314Response to radiation3.90E-09AKT1/JUN/CASP3/EGFR/MYC/HIF1A/MMP9/FOS/CCND1/CREB1
GO: 0000302Response to reactive oxygen species1.03E-09AKT1/IL-6/JUN/CASP3/EGFR/HIF1A/MAPK3/MMP9/FOS
GO: 0009416Response to light stimulus5.93E-09AKT1/CASP3/EGFR/MYC/HIF1A/MMP9/FOS/CCND1/CREB1
GO: 0042493Response to drug1.34E-08JUN/CASP3/IL-1B/EGFR/MYC/PPARG/FOS/CCND1/CREB1
GO: 0050679Positive regulation of epithelial cell proliferation5.93E-09AKT1/VEGFA/EGFR/MYC/HIF1A/EGF/CCND1/ERBB2
GO: 0030879Mammary gland development1.31E-08AKT1/VEGFA/ESR1/HIF1A/EGF/CCND1/CREB1
GO: 0034614Cellular response to reactive oxygen species4.37E-08AKT1/IL-6/JUN/EGFR/MAPK3/MMP9/FOS
GO: 0071276Cellular response to cadmium ion1.16E-09AKT1/JUN/EGFR/MAPK3/MMP9/FOS
GO: 0046686Response to cadmium ion8.07E-09AKT1/JUN/EGFR/MAPK3/MMP9/FOS
GO: 0060749Mammary gland alveolus development1.94E-09VEGFA/ESR1/HIF1A/EGF/CCND1
GO: 0061377Mammary gland lobule development1.94E-09VEGFA/ESR1/HIF1A/EGF/CCND1