Dracorhodin Perchlorate Regulates the Expression of Inflammatory Cytokines through the TLR4 Pathway and Improves Skin Wound Healing in Diabetic Rats

Figure 3

Effect of DP on inflammatory factors in rat skin. (a) mRNA expression of IL-1α in wound tissue at 7 d, 14 d, and 21 d; (b) mRNA expression of IL-1β in wound tissue at 7 d, 14 d, and 21 d; (c) mRNA expression of TNF-α in wound tissue at 7 d, 14 d, and 21 d; (d) mRNA expression of IL-6 in wound tissue at 7 d, 14 d, and 21 d; (e) protein content of IL-1β in wound tissue at 7 d, 14 d, and 21 d; (f) mRNA expression of IL-6 in wound tissue at 7 d, 14 d, and 21 d; (e) protein content of IL-1β in wound tissue at 7 d, 14 d, and 21 d; (f) protein content of TNF-α in wound tissue at 7 d, 14 d, and 21 d; (g) COX-2 positive staining in wound tissue at 7 d, 14 d, and 21 d, 20x, 50 μm; (h) COX-2 positive staining in wound tissue at 7 d, 14 d, and 21 d COX-2 positive cell rate in tissue at 7 d, 14 d, and 21 d. n = 10; versus control group. versus control group. ^# versus STZ group. ^## versus STZ group. Data are expressed as mean ± SEM.

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